Electrical signals in the ER are cell type and stimulus specific with extreme spatial compartmentalization in neurons
Evan P Campbell, Ahmed A Abushawish, Lauren A Valdez, Miriam K Bell, Melita Haryono, Padmini Rangamani, Brenda L Bloodgood
Cell. Volume 42, Issue 1. doi: 10.1016/j.celrep.2022.111943
All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors.
Puppo, F., Sadegh, S., Trujillo, C.A., Thunemann, M., Campbell, E.P., Vandenberghe, M., Shan, X., Akkouh, I., Miller, E., Bloodgood, B.L. and Silva, G.A.
Frontiers in Cellular Neuroscience, 15, p.197.
Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons
Xinyi Jenny He, Janki Patel, Connor E Weiss, Xiang Ma, Brenda L Bloodgood, Matthew R Banghart
eLife. 2021 Nov 17;10:e69746. doi: 10.7554/eLife.69746
Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon
Lauren E. McElvain, Yuncong Chen, Jeffrey D. Moore, G. Stefano Brigidi, Brenda L. Bloodgood, Byung Kook Lim, Rui M. Costa, David Kleinfeld
Neuron. 2021 May 19; Volume 109, Issue 10, p. 1721-1738.e4 doi: 10.1016/j.neuron.2021.03.017
Mechanisms that communicate features of neuronal activity to the genome
Daniel A Heinz, Brenda L Bloodgood
Cellular Neuroscience. August 2020; Volume 63, p. 131-136. doi: 10.1016/j.conb.2020.03.002
NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus.
Andrea L Hartzell, Kelly M Martyniuk, G Stefano Brigidi, Daniel A Heinz, Nathalie A Djaja, Anja Payne, Brenda L Bloodgood
eLife. 2018 Jul 27;7. pii: e35927. doi: 10.7554/eLife.35927.
Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex.
Laura Sancho, Brenda L. Bloodgood
Cell Rep. 2018 Aug 21;24(8):2075-2087. doi: 10.1016/j.celrep.2018.07.070.
Activity-dependent trafficking of lysosomes in dendrites and dendritic spines.
Goo MS, Sancho L, Slepak N, Boassa D, Deerinck TJ, Ellisman MH, Bloodgood BL, Patrick GN
J Cell Biol. 2017 Aug 7;216(8):2499-2513. doi: 10.1083/jcb.201704068. Epub 2017 Jun 19.
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death.
Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN
Brenda L. Bloodgood, Nikhil Sharma, Heidi Adlman Browne, Alissa Z. Trepman, Michael E. Greenberg
Historical
A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.
Soskis, M., Ho, HY., Bloodgood, B. et al.
Nat Neurosci 15, 1645–1654 (2012). https://doi.org/10.1038/nn.3249
The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc.
Paul L. Greer, Rikinari Hanayama, Brenda L Bloodgood, et al.
Cell, vol. 140, no. 5, 2010, pp. 704–716., https://doi.org/10.1016/j.cell.2010.01.026
Biphasic Synaptic Ca Influx Arising from Compartmentalized Electrical Signals in Dendritic Spines.
Bloodgood BL, Giessel AJ, Sabatini BL
PLoS Biol 7(9): e1000190. https://doi.org/10.1371/journal.pbio.1000190
NMDA Receptor-Mediated Calcium Transients in Dendritic Spines.
Bloodgood BL, Sabatini BL
Van Dongen AM, editor. Biology of the NMDA Receptor. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 9.
Activity-dependent regulation of inhibitory synapse development by Npas4.
Lin, Y., Bloodgood, B., Hauser, J. et al.
Nature 455, 1198–1204 (2008). https://doi.org/10.1038/nature07319
Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels
Bloodgood, B.L. and Sabatini, B.L.
The Journal of Physiology. 17 March 2008. Issue 586: p. 1475-1480. doi: 10.1113/jphysiol.2007.148353
Multiple Levels of Synaptic Regulation by NMDA-type Glutamate Receptor in Normal and Disease States
Alvarez V, Shankar G, Bloodgood B, Selkoe D, Sabatini B.
Synaptic Plasticity and the Mechanism of Alzheimer’s Disease. 2008. doi: 10.1007/978-3-540-76330-7_7
Ca2+ Signaling in Dendritic Spines
Brenda L. Bloodgood and Bernardo L. Sabatini
Current Opinion in Neurobiology, vol. 17, no. 3, 2007, pp. 345–351. doi: 10.1016/j.conb.2007.04.003.
Natural Oligomers of the Alzheimer Amyloid-𝛃 Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway
G. Shankar, B. Bloodgood, M. Townsend, D. Walsh, D. Selkoe and B. Sabatini
Journal of Neuroscience, vol. 27, no. 11, 2007, pp. 2866–2875. doi: 10.1523/jneurosci.4970-06.2007
Nonlinear Regulation of Unitary Synaptic Signals by CaV2.3 Voltage-Sensitive Calcium Channels Located in Dendritic Spines
Brenda L. Bloodgood, Bernardo L. Sabatini
Neuron, vol. 53, issue 2, 2007, pp. 249-260. doi: 10.1016/j.neuron.2006.12.017
Neuronal Activity Regulates Diffusion Across the Neck of Dendritic Spines
Brenda L. Bloodgood and Bernardo L. Sabatini
Science, 04 Nov 2005; Vol 310, Issue 5749, pp. 866-869. doi: 10.1126/science.1114816
SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines
T. Ngo-Anh, B. Bloodgood, M. Lin, B. Sabatini, J. Maylie & J. Adelman
Nat Neurosci 8, 2005, pp. 642-649. doi: 10.1038/nn1449