Electrical signals in the ER are cell type and stimulus specific with extreme spatial compartmentalization in neurons

Evan P Campbell, Ahmed A Abushawish, Lauren A Valdez, Miriam K Bell, Melita Haryono, Padmini Rangamani, Brenda L Bloodgood

Cell. Volume 42, Issue 1. doi: 10.1016/j.celrep.2022.111943

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors.

Puppo, F., Sadegh, S., Trujillo, C.A., Thunemann, M., Campbell, E.P., Vandenberghe, M., Shan, X., Akkouh, I., Miller, E., Bloodgood, B.L. and Silva, G.A.

Frontiers in Cellular Neuroscience, 15, p.197.

Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons

Xinyi Jenny He, Janki Patel, Connor E Weiss, Xiang Ma, Brenda L Bloodgood, Matthew R Banghart

eLife. 2021 Nov 17;10:e69746. doi: 10.7554/eLife.69746

Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon

Lauren E. McElvain, Yuncong Chen, Jeffrey D. Moore, G. Stefano Brigidi, Brenda L. Bloodgood, Byung Kook Lim, Rui M. Costa, David Kleinfeld

Neuron. 2021 May 19; Volume 109, Issue 10, p. 1721-1738.e4 doi: 10.1016/j.neuron.2021.03.017

Mechanisms that communicate features of neuronal activity to the genome

Daniel A Heinz, Brenda L Bloodgood

Cellular Neuroscience. August 2020; Volume 63, p. 131-136. doi: 10.1016/j.conb.2020.03.002

NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus.

Andrea L Hartzell, Kelly M Martyniuk, G Stefano Brigidi, Daniel A Heinz, Nathalie A Djaja, Anja Payne, Brenda L Bloodgood

eLife. 2018 Jul 27;7. pii: e35927. doi: 10.7554/eLife.35927.

Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex.

Laura Sancho, Brenda L. Bloodgood

Cell Rep. 2018 Aug 21;24(8):2075-2087. doi: 10.1016/j.celrep.2018.07.070.

Activity-dependent trafficking of lysosomes in dendrites and dendritic spines.

Goo MS, Sancho L, Slepak N, Boassa D, Deerinck TJ, Ellisman MH, Bloodgood BL, Patrick GN

J Cell Biol. 2017 Aug 7;216(8):2499-2513. doi: 10.1083/jcb.201704068. Epub 2017 Jun 19.

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death.

Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN

J Cell Biol. 2017 Apr 3;216(4):1091-1105. doi: 10.1083/jcb.201612067. Epub 2017 Mar 2.

Brenda L. Bloodgood, Nikhil Sharma, Heidi Adlman Browne, Alissa Z. Trepman, Michael E. Greenberg

Nature 503, 121–125 (07 November 2013) doi:10.1038/nature12743


A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.

Soskis, M., Ho, HY., Bloodgood, B. et al.

Nat Neurosci 15, 1645–1654 (2012).

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc.

Paul L. Greer, Rikinari Hanayama, Brenda L Bloodgood, et al.

Cell, vol. 140, no. 5, 2010, pp. 704–716.,

Biphasic Synaptic Ca Influx Arising from Compartmentalized Electrical Signals in Dendritic Spines.

Bloodgood BL, Giessel AJ, Sabatini BL

PLoS Biol 7(9): e1000190.

NMDA Receptor-Mediated Calcium Transients in Dendritic Spines.

Bloodgood BL, Sabatini BL

Van Dongen AM, editor. Biology of the NMDA Receptor. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 9.

Activity-dependent regulation of inhibitory synapse development by Npas4.

Lin, Y., Bloodgood, B., Hauser, J. et al.

Nature 455, 1198–1204 (2008).

Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels

Bloodgood, B.L. and Sabatini, B.L.

The Journal of Physiology. 17 March 2008. Issue 586: p. 1475-1480. doi: 10.1113/jphysiol.2007.148353

Multiple Levels of Synaptic Regulation by NMDA-type Glutamate Receptor in Normal and Disease States

Alvarez V, Shankar G, Bloodgood B, Selkoe D, Sabatini B.

Synaptic Plasticity and the Mechanism of Alzheimer’s Disease. 2008. doi: 10.1007/978-3-540-76330-7_7

Ca2+ Signaling in Dendritic Spines

Brenda L. Bloodgood and Bernardo L. Sabatini

Current Opinion in Neurobiology, vol. 17, no. 3, 2007, pp. 345–351. doi: 10.1016/j.conb.2007.04.003.

Natural Oligomers of the Alzheimer Amyloid-𝛃 Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

G. Shankar, B. Bloodgood, M. Townsend, D. Walsh, D. Selkoe and B. Sabatini

Journal of Neuroscience, vol. 27, no. 11, 2007, pp. 2866–2875. doi: 10.1523/jneurosci.4970-06.2007

Nonlinear Regulation of Unitary Synaptic Signals by CaV2.3 Voltage-Sensitive Calcium Channels Located in Dendritic Spines

Brenda L. Bloodgood, Bernardo L. Sabatini

Neuron, vol. 53, issue 2, 2007, pp. 249-260. doi: 10.1016/j.neuron.2006.12.017

Neuronal Activity Regulates Diffusion Across the Neck of Dendritic Spines

Brenda L. Bloodgood and Bernardo L. Sabatini

Science, 04 Nov 2005; Vol 310, Issue 5749, pp. 866-869. doi: 10.1126/science.1114816

SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines

T. Ngo-Anh, B. Bloodgood, M. Lin, B. Sabatini, J. Maylie & J. Adelman

Nat Neurosci 8, 2005, pp. 642-649. doi: 10.1038/nn1449